The structure of anthracycline derivatives determines their subcellular localization and cytotoxic activity.
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ABSTRACT:
SUBMITTER: Shaul P
PROVIDER: S-EPMC4027571 | biostudies-literature | 2013 Mar
REPOSITORIES: biostudies-literature
Publications
The structure of anthracycline derivatives determines their subcellular localization and cytotoxic activity.
Shaul Pazit P Frenkel Michael M Goldstein Elinor Briner EB Mittelman Leonid L Grunwald Assaf A Ebenstein Yuval Y Tsarfaty Ilan I Fridman Micha M
ACS medicinal chemistry letters 20130204 3
The cytotoxic activities and subcellular localizations of clinically used and synthetic analogues of the anthracycline family of chemotherapeutic agents were studied. The structures of the anthracycline derivatives affected their cytotoxicity and the time required for these compounds to exert cytotoxic effects on tumor cells. Fluorescent DNA intercalator displacement experiments demonstrated that there was no correlation between the DNA intercalation properties and the cytotoxicity of the studie ...[more]
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