Ontology highlight
ABSTRACT:
SUBMITTER: Sogabe S
PROVIDER: S-EPMC4027575 | biostudies-literature | 2013 Feb
REPOSITORIES: biostudies-literature
ACS medicinal chemistry letters 20121218 2
The epidermal growth factor receptor (EGFR) family plays a critical role in vital cellular processes and in various cancers. Known EGFR inhibitors exhibit distinct antitumor responses against the various EGFR mutants associated with nonsmall-cell lung cancer. The L858R mutation enhances clinical sensitivity to gefitinib and erlotinib as compared with wild type and reduces the relative sensitivity to lapatinib. In contrast, the T790M mutation confers drug resistance to gefitinib and erlotinib. We ...[more]