Rationale for therapeutic silencing of alpha-synuclein in Parkinson's disease.
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ABSTRACT:
SUBMITTER: Maraganore DM
PROVIDER: S-EPMC4027709 | biostudies-literature | 2011 May
REPOSITORIES: biostudies-literature
Publications
Rationale for therapeutic silencing of alpha-synuclein in Parkinson's disease.
Journal of movement disorders 20110430 1
The purpose of this paper is to provide the rationale for therapeutic silencing of the alpha-synuclein gene (SNCA) in Parkinson's disease (PD). The paper reviews the public health significance of PD; the causal links between rare SNCA variants and familial PD; the association of common SNCA variants and PD susceptibility; the association of SNCA variants also with age at onset and motor and cognitive outcomes in PD; therapeutic strategies targeting SNCA in PD; and preliminary findings and consid ...[more]
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