Ontology highlight
ABSTRACT:
SUBMITTER: Strong AL
PROVIDER: S-EPMC4027770 | biostudies-literature | 2014 Feb
REPOSITORIES: biostudies-literature
Strong Amy L AL Jiang Quan Q Zhang Qiang Q Zheng Shilong S Boue Stephen M SM Elliott Steven S Burow Matthew E ME Bunnell Bruce A BA Wang Guangdi G
ACS medicinal chemistry letters 20131210 2
Osteoporosis is caused by an overstimulation of osteoclast activity and the destruction of the bone extracellular matrix. Without the normal architecture, osteoblast cells are unable to rebuild phenotypically normal bone. Hormone replacement therapy with estrogen has been effective in increasing osteoblast activity but also has resulted in the increased incidence of breast and uterine cancer. In this study we designed and synthesized a series of daidzein analogs to investigate their osteogenic i ...[more]