Ontology highlight
ABSTRACT:
SUBMITTER: Gilchrist J
PROVIDER: S-EPMC4027953 | biostudies-literature | 2014 May
REPOSITORIES: biostudies-literature
Gilchrist John J Dutton Stacey S Diaz-Bustamante Marcelo M McPherson Annie A Olivares Nicolas N Kalia Jeet J Escayg Andrew A Bosmans Frank F Bosmans Frank F
ACS chemical biology 20140331 5
Here, we report the discovery of a novel anticonvulsant drug with a molecular organization based on the unique scaffold of rufinamide, an anti-epileptic compound used in a clinical setting to treat severe epilepsy disorders such as Lennox-Gastaut syndrome. Although accumulating evidence supports a working mechanism through voltage-gated sodium (Nav) channels, we found that a clinically relevant rufinamide concentration inhibits human (h)Nav1.1 activation, a distinct working mechanism among antic ...[more]