Ontology highlight
ABSTRACT:
SUBMITTER: Craig ZR
PROVIDER: S-EPMC4028413 | biostudies-literature | 2014 Jun
REPOSITORIES: biostudies-literature
Reproductive toxicology (Elmsford, N.Y.) 20140109
Mono-2-ethyhexyl phthalate (MEHP) is a metabolite of a plasticizer found in many consumer products. MEHP inhibits mouse ovarian follicle growth by reducing 17β-estradiol (E2) production. Yet, whether MEHP causes follicle death (atresia) is unclear. We hypothesized that MEHP causes atresia by altering apoptosis gene expression, and that E2 co-treatment blocks these effects. Follicles were exposed to MEHP (0.36-36μM)±E2 for 48-96h to determine the effect of MEHP±E2 on atresia and gene expression. ...[more]