Triptolide sensitizes pancreatic cancer cells to TRAIL-induced activation of the death receptor pathway.
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ABSTRACT:
SUBMITTER: Chen Z
PROVIDER: S-EPMC4028717 | biostudies-literature | 2014 Jun
REPOSITORIES: biostudies-literature
Publications
Triptolide sensitizes pancreatic cancer cells to TRAIL-induced activation of the death receptor pathway.
Chen Zhiyu Z Sangwan Veena V Banerjee Sulagna S Chugh Rohit R Dudeja Vikas V Vickers Selwyn M SM Saluja Ashok K AK
Cancer letters 20140321 1-2
The tumor necrosis factor related apoptosis-inducing ligand (TRAIL) causes cancer cell death, but many cancers, including pancreatic cancer, are resistant to TRAIL therapy. A combination of TRAIL and the diterpene triepoxide, triptolide, is effective in inducing pancreatic cancer cell death. Triptolide increases levels of death receptor DR5 and decreases the pro-survival FLICE-like inhibitory protein (c-FLIP), which contribute to the activation of caspase-8. This combination further causes both ...[more]
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