Ontology highlight
ABSTRACT:
SUBMITTER: Wu R
PROVIDER: S-EPMC4029408 | biostudies-literature | 2011 Oct
REPOSITORIES: biostudies-literature
Wu Rongling R Tong Chunfa C Wang Zhong Z Mauger David D Tantisira Kelan K Szefler Stanley J SJ Chinchilli Vernon M VM Israel Elliot E
Drug discovery today 20110906 19-20
Genome-wide association studies (GWAS) have emerged as a powerful tool to identify loci that affect drug response or susceptibility to adverse drug reactions. However, current GWAS based on a simple analysis of associations between genotype and phenotype ignores the biochemical reactions of drug response, thus limiting the scope of inference about its genetic architecture. To facilitate the inference of GWAS in pharmacogenomics, we sought to undertake the mathematical integration of the pharmaco ...[more]