STAT inhibitors for cancer therapy.
Ontology highlight
ABSTRACT:
SUBMITTER: Furqan M
PROVIDER: S-EPMC4029528 | biostudies-literature | 2013 Dec
REPOSITORIES: biostudies-literature
Publications
STAT inhibitors for cancer therapy.
Furqan Muhammad M Akinleye Akintunde A Mukhi Nikhil N Mittal Varun V Chen Yamei Y Liu Delong D
Journal of hematology & oncology 20131205
Signal Transducer and Activator of Transcription (STAT) proteins are a family of cytoplasmic transcription factors consisting of 7 members, STAT1 to STAT6, including STAT5a and STAT5b. STAT proteins are thought to be ideal targets for anti-cancer therapy since cancer cells are more dependent on the STAT activity than their normal counterparts. Inhibitors targeting STAT3 and STAT5 have been developed. These included peptidomimetics, small molecule inhibitors and oligonucleotides. This review summ ...[more]
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