Dataset Information

Selected cytokines in patients with pancreatic cancer: a preliminary report.

ABSTRACT:

Background/aims

Recent experimental studies have suggested that various cytokines may be important players in the development and progression of pancreatic cancer. However, these findings have not yet been verified in a clinical setting.

Methods

In this study, we examined the levels of a broad panel of cytokines, including interleukin (IL)-1, IL-6, IL-8, IL-10, IL-12, IL-17, and IL-23, as well as tumor necrosis factor alpha (TNF?) and granulocyte-colony stimulating factor (G-CSF) in patients with pancreatic adenocarcinoma (n=43), other pancreatic malignancies (neuroendocrine [n=10] and solid pseudopapillary tumors [n=3]), and healthy individuals (n=41).

Results

We found that there were higher levels of IL-6, IL-8, IL-10 and TNF? in patients with pancreatic cancer compared to healthy controls (for all, at least p<0.03). Cancer patients had lower IL-23 concentrations than healthy individuals and patients diagnosed with other types of malignancies (for both, p=0.002). Levels of IL-6, IL-8, IL-10, and IL-23 were significantly associated with the direct number of circulating bone marrow (BM)-derived mesenchymal or very small embryonic/epiblast-like stem cells (SCs) in patients with pancreatic cancer. Moreover, our study identified a potential ability of IL-6, IL-8, IL-10, IL-23, and TNF? levels to enable discrimination of pancreatic cancer from other pancreatic tumors and diseases, including acute and chronic pancreatitis and post-pancreatitis cysts (with sensitivity and specificity ranging between 70%-82%).

Conclusions

Our study i) supports the significance of selected cytokines in the clinical presentation of pancreatic cancer, ii) highlights numerous associations between selected interleukins and intensified BMSCs trafficking in patients with pancreatic cancer, and iii) preliminarily characterizes the diagnostic potential of several cytokines as potential novel clinical markers of pancreatic cancer in humans.

SUBMITTER: Blogowski W

PROVIDER: S-EPMC4029741 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature

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Publications

Selected cytokines in patients with pancreatic cancer: a preliminary report.

Błogowski Wojciech W Deskur Anna A Budkowska Marta M Sałata Daria D Madej-Michniewicz Anna A Dąbkowski Krzysztof K Dołęgowska Barbara B Starzyńska Teresa T

PloS one 20140521 5

<h4>Background/aims</h4>Recent experimental studies have suggested that various cytokines may be important players in the development and progression of pancreatic cancer. However, these findings have not yet been verified in a clinical setting.<h4>Methods</h4>In this study, we examined the levels of a broad panel of cytokines, including interleukin (IL)-1, IL-6, IL-8, IL-10, IL-12, IL-17, and IL-23, as well as tumor necrosis factor alpha (TNFα) and granulocyte-colony stimulating factor (G-CSF) ...[more]

PMID: 24849506

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Dataset Information

Selected cytokines in patients with pancreatic cancer: a preliminary report.

Background/aims

Methods

Results

Conclusions

Publications

Selected cytokines in patients with pancreatic cancer: a preliminary report.

Similar Datasets

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