Ontology highlight
ABSTRACT:
SUBMITTER: Soave D
PROVIDER: S-EPMC4030111 | biostudies-literature | 2014 Jun
REPOSITORIES: biostudies-literature
Soave David D Miller Melissa R MR Keenan Katherine K Li Weili W Gong Jiafen J Ip Wan W Accurso Frank F Sun Lei L Rommens Johanna M JM Sontag Marci M Durie Peter R PR Strug Lisa J LJ
Diabetes 20140218 6
Circulating immunoreactive trypsinogen (IRT), a biomarker of exocrine pancreatic disease in cystic fibrosis (CF), is elevated in most CF newborns. In those with severe CF transmembrane conductance regulator (CFTR) genotypes, IRT declines rapidly in the first years of life, reflecting progressive pancreatic damage. Consistent with this progression, a less elevated newborn IRT measure would reflect more severe pancreatic disease, including compromised islet compartments, and potentially increased ...[more]