Ontology highlight
ABSTRACT:
SUBMITTER: Morrison AC
PROVIDER: S-EPMC4030301 | biostudies-literature | 2013 Aug
REPOSITORIES: biostudies-literature
Morrison Alanna C AC Voorman Arend A Johnson Andrew D AD Liu Xiaoming X Yu Jin J Li Alexander A Muzny Donna D Yu Fuli F Rice Kenneth K Zhu Chengsong C Bis Joshua J Heiss Gerardo G O'Donnell Christopher J CJ Psaty Bruce M BM Cupples L Adrienne LA Gibbs Richard R Boerwinkle Eric E
Nature genetics 20130616 8
We describe initial steps for interrogating whole-genome sequence data to characterize the genetic architecture of a complex trait, levels of high-density lipoprotein cholesterol (HDL-C). We report whole-genome sequencing and analysis of 962 individuals from the Cohorts for Heart and Aging Research in Genetic Epidemiology (CHARGE) studies. From this analysis, we estimate that common variation contributes more to heritability of HDL-C levels than rare variation, and screening for mendelian varian ...[more]