Ontology highlight
ABSTRACT:
SUBMITTER: Covino R
PROVIDER: S-EPMC4030985 | biostudies-literature | 2014
REPOSITORIES: biostudies-literature
Covino Roberto R Skrbić Tatjana T Beccara Silvio A SA Faccioli Pietro P Micheletti Cristian C
Biomolecules 20131224 1
For several decades, the presence of knots in naturally-occurring proteins was largely ruled out a priori for its supposed incompatibility with the efficiency and robustness of folding processes. For this very same reason, the later discovery of several unrelated families of knotted proteins motivated researchers to look into the physico-chemical mechanisms governing the concerted sequence of folding steps leading to the consistent formation of the same knot type in the same protein location. Be ...[more]