Ontology highlight
ABSTRACT:
SUBMITTER: Chen KY
PROVIDER: S-EPMC4031050 | biostudies-literature | 2014 May
REPOSITORIES: biostudies-literature
Chen Kuang-Yui M KY Sun Jiaming J Salvo Jason S JS Baker David D Barth Patrick P
PLoS computational biology 20140522 5
Eukaryotic transmembrane helical (TMH) proteins perform a wide diversity of critical cellular functions, but remain structurally largely uncharacterized and their high-resolution structure prediction is currently hindered by the lack of close structural homologues. To address this problem, we present a novel and generic method for accurately modeling large TMH protein structures from distant homologues exhibiting distinct loop and TMH conformations. Models of the adenosine A2AR and chemokine CXC ...[more]