The changing geometry of a fitness landscape along an adaptive walk.
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ABSTRACT:
SUBMITTER: Greene D
PROVIDER: S-EPMC4031059 | biostudies-literature | 2014 May
REPOSITORIES: biostudies-literature
Publications
The changing geometry of a fitness landscape along an adaptive walk.
Greene Devin D Crona Kristina K
PLoS computational biology 20140522 5
It has recently been noted that the relative prevalence of the various kinds of epistasis varies along an adaptive walk. This has been explained as a result of mean regression in NK model fitness landscapes. Here we show that this phenomenon occurs quite generally in fitness landscapes. We propose a simple and general explanation for this phenomenon, confirming the role of mean regression. We provide support for this explanation with simulations, and discuss the empirical relevance of our findin ...[more]
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