Ontology highlight
ABSTRACT:
SUBMITTER: Petriv OI
PROVIDER: S-EPMC4031183 | biostudies-literature | 2014
REPOSITORIES: biostudies-literature
PloS one 20140522 5
The efficient use of digital PCR (dPCR) for precision copy number analysis requires high concentrations of target molecules that may be difficult or impossible to obtain from clinical samples. To solve this problem we present a strategy, called Multiplex Template Sampling (MTS), that effectively increases template concentrations by detecting multiple regions of fragmented target molecules. Three alternative assay approaches are presented for implementing MTS analysis of chromosome 21, providing ...[more]