Resistance to Raf inhibition in cancer.
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ABSTRACT:
SUBMITTER: Haarberg HE
PROVIDER: S-EPMC4031441 | biostudies-literature | 2014 Mar
REPOSITORIES: biostudies-literature
Publications
Resistance to Raf inhibition in cancer.
Haarberg H Eirik HE Smalley Keiran S M KS
Drug discovery today. Technologies 20140301
The use of small molecule BRAF inhibitors has revolutionized the treatment of advanced melanoma. Despite this, resistance is commonplace and associated with a median progression-free survival of >5 months. Major resistance mechanisms include reactivation of the MAPK pathway and increased PI3K/AKT signaling. Here we review some of the combination therapeutic strategies currently undergoing evaluation for the management of acquired drug resistance in melanoma. ...[more]
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