Ontology highlight
ABSTRACT:
SUBMITTER: Kim DS
PROVIDER: S-EPMC4031948 | biostudies-literature | 2014 Jun
REPOSITORIES: biostudies-literature
Kim Daniel Seung DS Crosslin David R DR Auer Paul L PL Suzuki Stephanie M SM Marsillach Judit J Burt Amber A AA Gordon Adam S AS Meschia James F JF Nalls Mike A MA Worrall Bradford B BB Longstreth W T WT Gottesman Rebecca F RF Furlong Clement E CE Peters Ulrike U Rich Stephen S SS Nickerson Deborah A DA Jarvik Gail P GP
Journal of lipid research 20140407 6
HDL-associated paraoxonase-1 (PON1) is an enzyme whose activity is associated with cerebrovascular disease. Common PON1 genetic variants have not been consistently associated with cerebrovascular disease. Rare coding variation that likely alters PON1 enzyme function may be more strongly associated with stroke. The National Heart, Lung, and Blood Institute Exome Sequencing Project sequenced the coding regions (exomes) of the genome for heart, lung, and blood-related phenotypes (including ischemic ...[more]