Ontology highlight
ABSTRACT:
SUBMITTER: Ember SW
PROVIDER: S-EPMC4032195 | biostudies-literature | 2014 May
REPOSITORIES: biostudies-literature
ACS chemical biology 20140313 5
Members of the bromodomain and extra terminal (BET) family of proteins are essential for the recognition of acetylated lysine (KAc) residues in histones and have emerged as promising drug targets in cancer, inflammation, and contraception research. In co-crystallization screening campaigns using the first bromodomain of BRD4 (BRD4-1) against kinase inhibitor libraries, we identified and characterized 14 kinase inhibitors (10 distinct chemical scaffolds) as ligands of the KAc binding site. Among ...[more]