Dataset Information

AMPD1 rs17602729 is associated with physical performance of sprint and power in elite Lithuanian athletes.

ABSTRACT: BACKGROUND: The C34T genetic polymorphism (rs17602729) in the AMPD1 gene, encoding the skeletal muscle-specific isoform of adenosine monophosphate deaminase (AMPD1), is a common polymorphism among Caucasians that can impair exercise capacity. The aim of the present study was twofold: (1) to determine the C34T AMPD1 allele/genotype frequency distributions in Lithuanian athletes (n?=?204, stratified into three groups: endurance, sprint/power and mixed) and compare them with the allele/genotype frequency distributions in randomly selected healthy Lithuanian non-athletes (n?=?260) and (2) to compare common anthropometric measurements and physical performance phenotypes between the three groups of athletes depending on their AMPD1 genotype. RESULTS: The results of our study indicate that the frequency of the AMPD1 TT genotype was 2.4% in the control group, while it was absent in the athlete group. There were significantly more sprint/power-orientated athletes with the CC genotype (86.3%) compared with the endurance-orientated athletes (72.9%), mixed athletes (67.1%), and controls (74.2%). We determined that the AMPD1 C34T polymorphism is not associated with aerobic muscle performance phenotype (VO2max). For CC genotype the short-term explosive muscle power value (based on Vertical Jump test) of athletes from the sprint/power group was significantly higher than that of the endurance group athletes (P?

SUBMITTER: Gineviciene V

PROVIDER: S-EPMC4032451 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature

ACCESS DATA

Publications

AMPD1 rs17602729 is associated with physical performance of sprint and power in elite Lithuanian athletes.

Ginevičienė Valentina V Jakaitienė Audronė A Pranculis Aidas A Milašius Kazys K Tubelis Linas L Utkus Algirdas A

BMC genetics 20140517

<h4>Background</h4>The C34T genetic polymorphism (rs17602729) in the AMPD1 gene, encoding the skeletal muscle-specific isoform of adenosine monophosphate deaminase (AMPD1), is a common polymorphism among Caucasians that can impair exercise capacity. The aim of the present study was twofold: (1) to determine the C34T AMPD1 allele/genotype frequency distributions in Lithuanian athletes (n = 204, stratified into three groups: endurance, sprint/power and mixed) and compare them with the allele/genot ...[more]

PMID: 24885427

Similar Datasets

Project description:Actually, there is scarce literature looking for the relationship between inter-limb asymmetries and performance in youth elite team sports. The main purpose of this cross-sectional study was to examine the relationships between inter-limb asymmetries and physical performance in youth elite team-sports players. A secondary objective was to evaluate the presence of between-sexes differences in inter-limb asymmetries in elite youth team sports players. Eighty-one young elite team-sports athletes (age: u-14 to u-18) performed the star excursion balance test in the anterior direction (SEBT ANT), a single leg vertical countermovement jump test (SLCMJ), the one leg hop test for distance (OLHT), a 30 m sprint test, and the V-cut test. Inter-limb asymmetries were calculated for SEBT ANT, SLCMJ and OLHT. Pearson r was used to analyse the relationships between inter-limb asymmetries and physical performance. Results showed significant (p < 0.05) but small (r = 0.26) relationships between SLCMJ asymmetries and 30 m sprint time for the total group. Significant negative correlations with small to moderate magnitude of correlation were also found between SLCMJ asymmetries and SLCMJ performance on the lowest performing limb for the total group (p < 0.05; r = -0.26), males (p < 0.01; r = -0.48) and females (p < 0.05; r = -0.30). Moreover, significant negative correlations with moderate and large magnitude were also present between OLHT asymmetries and OLHT performance on the lowest performing limb for the total group (p < 0.01; r = -0.44), males (p < 0.01; r = -0.56) and females (p < 0.01; r = -0.64). No correlations were observed between asymmetries and either the V-cut test or SEBT ANT performance. No correlation were observed between SEBT ANT asymmetries and physical performance. In addition, when comparing asymmetry values between sexes there were no significant differences in vertical (p = 0.06) and horizontal (p = 0.61) jumping tests. However, there were significant differences in asymmetry between sexes in the ANT SEBT (p = 0.04). In conclusion, the current study indicated that jumping asymmetries were associated with decrements in sprint speed and jumping performance. Therefore, assessing inter-limb asymmetries would be recommended to improve training interventions for youth elite team-sports athletes.

Project description:PurposeThe main aim of this investigation was to quantify differences in sprint mechanical variables across sports and within each sport. Secondary aims were to quantify sex differences and relationships among the variables.MethodsIn this cross-sectional study of elite athletes, 235 women (23 ± 5 y and 65 ± 7 kg) and 431 men (23 ± 4 y and 80 ± 12 kg) from 23 different sports (including 128 medalists from World Championships and/or Olympic Games) were tested in a 40-m sprint at the Norwegian Olympic Training Center between 1995 and 2018. These were pre-existing data from quarterly or semi-annual testing that the athletes performed for training purposes. Anthropometric and speed-time sprint data were used to calculate the theoretical maximal velocity, horizontal force, horizontal power, slope of the force-velocity relationship, maximal ratio of force, and index of force application technique.ResultsSubstantial differences in mechanical profiles were observed across sports. Athletes in sports in which sprinting ability is an important predictor of success (e.g., athletics sprinting, jumping and bobsleigh) produced the highest values for most variables, whereas athletes in sports in which sprinting ability is not as important tended to produce substantially lower values. The sex differences ranged from small to large, depending on variable of interest. Although most of the variables were strongly associated with 10- and 40-m sprint time, considerable individual differences in sprint mechanical variables were observed among equally performing athletes.ConclusionsOur data from a large sample of elite athletes tested under identical conditions provides a holistic picture of the force-velocity-power profile continuum in athletes. The data indicate that sprint mechanical variables are more individual than sport specific. The values presented in this study could be used by coaches to develop interventions that optimize the training stimulus to the individual athlete.

Dataset Information

AMPD1 rs17602729 is associated with physical performance of sprint and power in elite Lithuanian athletes.

Publications

AMPD1 rs17602729 is associated with physical performance of sprint and power in elite Lithuanian athletes.

Similar Datasets

OmicsDI is part of the ELIXIR infrastructure

Tweets