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AMPD1 rs17602729 is associated with physical performance of sprint and power in elite Lithuanian athletes.

ABSTRACT: BACKGROUND: The C34T genetic polymorphism (rs17602729) in the AMPD1 gene, encoding the skeletal muscle-specific isoform of adenosine monophosphate deaminase (AMPD1), is a common polymorphism among Caucasians that can impair exercise capacity. The aim of the present study was twofold: (1) to determine the C34T AMPD1 allele/genotype frequency distributions in Lithuanian athletes (n?=?204, stratified into three groups: endurance, sprint/power and mixed) and compare them with the allele/genotype frequency distributions in randomly selected healthy Lithuanian non-athletes (n?=?260) and (2) to compare common anthropometric measurements and physical performance phenotypes between the three groups of athletes depending on their AMPD1 genotype. RESULTS: The results of our study indicate that the frequency of the AMPD1 TT genotype was 2.4% in the control group, while it was absent in the athlete group. There were significantly more sprint/power-orientated athletes with the CC genotype (86.3%) compared with the endurance-orientated athletes (72.9%), mixed athletes (67.1%), and controls (74.2%). We determined that the AMPD1 C34T polymorphism is not associated with aerobic muscle performance phenotype (VO2max). For CC genotype the short-term explosive muscle power value (based on Vertical Jump test) of athletes from the sprint/power group was significantly higher than that of the endurance group athletes (P?

SUBMITTER: Gineviciene V

PROVIDER: S-EPMC4032451 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature

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AMPD1 rs17602729 is associated with physical performance of sprint and power in elite Lithuanian athletes.

Ginevičienė Valentina V Jakaitienė Audronė A Pranculis Aidas A Milašius Kazys K Tubelis Linas L Utkus Algirdas A

BMC genetics 20140517

<h4>Background</h4>The C34T genetic polymorphism (rs17602729) in the AMPD1 gene, encoding the skeletal muscle-specific isoform of adenosine monophosphate deaminase (AMPD1), is a common polymorphism among Caucasians that can impair exercise capacity. The aim of the present study was twofold: (1) to determine the C34T AMPD1 allele/genotype frequency distributions in Lithuanian athletes (n = 204, stratified into three groups: endurance, sprint/power and mixed) and compare them with the allele/genot ...[more]

PMID: 24885427

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AMPD1 rs17602729 is associated with physical performance of sprint and power in elite Lithuanian athletes.

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AMPD1 rs17602729 is associated with physical performance of sprint and power in elite Lithuanian athletes.

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