Multiple regression analysis of mRNA-miRNA associations in colorectal cancer pathway.
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ABSTRACT:
SUBMITTER: Wang F
PROVIDER: S-EPMC4033420 | biostudies-literature | 2014
REPOSITORIES: biostudies-literature
Publications
Multiple regression analysis of mRNA-miRNA associations in colorectal cancer pathway.
Wang Fengfeng F Wong S C Cesar SC Chan Lawrence W C LW Cho William C S WC Yip S P SP Yung Benjamin Y M BY
BioMed research international 20140507
<h4>Background</h4>MicroRNA (miRNA) is a short and endogenous RNA molecule that regulates posttranscriptional gene expression. It is an important factor for tumorigenesis of colorectal cancer (CRC), and a potential biomarker for diagnosis, prognosis, and therapy of CRC. Our objective is to identify the related miRNAs and their associations with genes frequently involved in CRC microsatellite instability (MSI) and chromosomal instability (CIN) signaling pathways.<h4>Results</h4>A regression model ...[more]
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