Ontology highlight
ABSTRACT:
SUBMITTER: Carney CE
PROVIDER: S-EPMC4033656 | biostudies-literature | 2014 May
REPOSITORIES: biostudies-literature
Carney Christiane E CE MacRenaris Keith W KW Mastarone Daniel J DJ Kasjanski David R DR Hung Andy H AH Meade Thomas J TJ
Bioconjugate chemistry 20140509 5
Cell tracking in vivo with MR imaging requires the development of contrast agents with increased sensitivity that effectively label and are retained by cells. Most clinically approved Gd(III)-based contrast agents require high incubation concentrations and prolonged incubation times for cellular internalization. Strategies to increase contrast agent permeability have included conjugating Gd(III) complexes to cell penetrating peptides, nanoparticles, and small molecules which have greatly improve ...[more]