Ontology highlight
ABSTRACT:
SUBMITTER: Matson DR
PROVIDER: S-EPMC4033774 | biostudies-literature | 2014 May
REPOSITORIES: biostudies-literature
Matson Daniel R DR Stukenberg P Todd PT
The Journal of cell biology 20140501 4
The RZZ (Rod, ZW10, and Zwilch) complex and Mad1 proteins tightly associate with kinetochores to generate the spindle checkpoint signal, but they are released when a kinetochore forms mature microtubule attachments. Here we demonstrate that the centromere protein CENP-I is required to generate a stable association of RZZ and Mad1 with kinetochores. CENP-I also inhibits their removal by dynein stripping. This regulation of Mad1 and RZZ dissociation functions independently of Aurora B, which regul ...[more]