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Dye-doped silica nanoparticles as efficient labels for glycans.

ABSTRACT: We report that dye-doped fluorescent silica nanoparticles (FSNPs) are highly efficient labels for glycans. Mono- and oligo-saccharides were conjugated to FSNPs using a general photocoupling chemistry. FSNP-labeled glycans were applied to image and detect bacteria, and to study carbohydrate-lectin interactions on a lectin microarray.

SUBMITTER: Wang X 

PROVIDER: S-EPMC4034181 | biostudies-literature | 2011 Apr

REPOSITORIES: biostudies-literature

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Dye-doped silica nanoparticles as efficient labels for glycans.

Wang Xin X   Ramström Olof O   Yan Mingdi M  

Chemical communications (Cambridge, England) 20110307 14

We report that dye-doped fluorescent silica nanoparticles (FSNPs) are highly efficient labels for glycans. Mono- and oligo-saccharides were conjugated to FSNPs using a general photocoupling chemistry. FSNP-labeled glycans were applied to image and detect bacteria, and to study carbohydrate-lectin interactions on a lectin microarray. ...[more]

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