Ontology highlight
ABSTRACT:
SUBMITTER: Man SM
PROVIDER: S-EPMC4034195 | biostudies-literature | 2014 May
REPOSITORIES: biostudies-literature
Man Si Ming SM Hopkins Lee J LJ Nugent Eileen E Cox Susan S Glück Ivo M IM Tourlomousis Panagiotis P Wright John A JA Cicuta Pietro P Monie Tom P TP Bryant Clare E CE
Proceedings of the National Academy of Sciences of the United States of America 20140506 20
Pathogen recognition by nucleotide-binding oligomerization domain-like receptor (NLR) results in the formation of a macromolecular protein complex (inflammasome) that drives protective inflammatory responses in the host. It is thought that the number of inflammasome complexes forming in a cell is determined by the number of NLRs being activated, with each NLR initiating its own inflammasome assembly independent of one another; however, we show here that the important foodborne pathogen Salmonell ...[more]