Ontology highlight
ABSTRACT:
SUBMITTER: Zhang L
PROVIDER: S-EPMC4034226 | biostudies-literature | 2014 May
REPOSITORIES: biostudies-literature
Zhang Liping L Syed Zulfeqhar Ali ZA van Dijk Härd Iris I Lim Jae-Min JM Wells Lance L Ten Hagen Kelly G KG
Proceedings of the National Academy of Sciences of the United States of America 20140505 20
Polarized secretion is crucial in many tissues. The conserved protein modification, O-glycosylation, plays a role in regulating secretion. However, the mechanisms by which this occurs are unknown. Here, we demonstrate that an O-glycosyltransferase functions as a novel regulator of secretion and secretory vesicle formation in vivo by glycosylating the essential Golgi/endoplasmic reticulum protein, Tango1 (Transport and Golgi organization 1), and conferring protection from furin-mediated proteolys ...[more]