Understanding the pharmacological properties of a metabolic PET tracer in prostate cancer.
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ABSTRACT:
SUBMITTER: Viola-Villegas NT
PROVIDER: S-EPMC4034234 | biostudies-literature | 2014 May
REPOSITORIES: biostudies-literature
Publications
Understanding the pharmacological properties of a metabolic PET tracer in prostate cancer.
Viola-Villegas Nerissa Therese NT Carlin Sean D SD Ackerstaff Ellen E Sevak Kuntal K KK Divilov Vadim V Serganova Inna I Kruchevsky Natalia N Anderson Michael M Blasberg Ronald G RG Andreev Oleg A OA Engelman Donald M DM Koutcher Jason A JA Reshetnyak Yana K YK Lewis Jason S JS
Proceedings of the National Academy of Sciences of the United States of America 20140501 20
Generally, solid tumors (>400 mm(3)) are inherently acidic, with more aggressive growth producing greater acidity. If the acidity could be targeted as a biomarker, it would provide a means to gauge the pace of tumor growth and degree of invasiveness, as well as providing a basis for predicting responses to pH-dependent chemotherapies. We have developed a (64)Cu pH (low) insertion peptide (pHLIP) for targeting, imaging, and quantifying acidic tumors by PET, and our findings reveal utility in asse ...[more]
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