Ontology highlight
ABSTRACT:
SUBMITTER: Stawicki TM
PROVIDER: S-EPMC4034270 | biostudies-literature | 2011 May
REPOSITORIES: biostudies-literature
Stawicki Tamara M TM Zhou Keming K Yochem John J Chen Lihsia L Jin Yishi Y
Current biology : CB 20110505 10
Neuronal networks operate over a wide range of activity levels, with both neuronal and nonneuronal cells contributing to the balance of excitation and inhibition. Activity imbalance within neuronal networks underlies many neurological diseases, such as epilepsy. The Caenorhabditis elegans locomotor circuit operates via coordinated activity of cholinergic excitatory and GABAergic inhibitory transmission. We have previously shown that a gain-of-function mutation in a neuronal acetylcholine recepto ...[more]