Ontology highlight
ABSTRACT:
SUBMITTER: Farid TA
PROVIDER: S-EPMC4034760 | biostudies-literature | 2013 Dec
REPOSITORIES: biostudies-literature
Farid Tammer A TA Kodali Goutham G Solomon Lee A LA Lichtenstein Bruce R BR Sheehan Molly M MM Fry Bryan A BA Bialas Chris C Ennist Nathan M NM Siedlecki Jessica A JA Zhao Zhenyu Z Stetz Matthew A MA Valentine Kathleen G KG Anderson J L Ross JLR Wand A Joshua AJ Discher Bohdana M BM Moser Christopher C CC Dutton P Leslie PL
Nature chemical biology 20131013 12
Emulating functions of natural enzymes in man-made constructs has proven challenging. Here we describe a man-made protein platform that reproduces many of the diverse functions of natural oxidoreductases without importing the complex and obscure interactions common to natural proteins. Our design is founded on an elementary, structurally stable 4-α-helix protein monomer with a minimalist interior malleable enough to accommodate various light- and redox-active cofactors and with an exterior toler ...[more]