Microfluidic source-sink model reveals effects of biophysically distinct CXCL12 isoforms in breast cancer chemotaxis.
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ABSTRACT:
SUBMITTER: Cavnar SP
PROVIDER: S-EPMC4034763 | biostudies-literature | 2014 May
REPOSITORIES: biostudies-literature
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Microfluidic source-sink model reveals effects of biophysically distinct CXCL12 isoforms in breast cancer chemotaxis.
Cavnar S P SP Ray P P Moudgil P P Chang S L SL Luker K E KE Linderman J J JJ Takayama S S Luker G D GD
Integrative biology : quantitative biosciences from nano to macro 20140501 5
Chemokines critically regulate chemotaxis in normal and pathologic states, but there is limited understanding of how multicellular interactions generate gradients needed for cell migration. Previous studies of chemotaxis of CXCR4+ cells toward chemokine CXCL12 suggest the requirement of cells expressing scavenger receptor CXCR7 in a source-sink system. We leveraged an established microfluidic device to discover that chemotaxis of CXCR4 cells toward distinct isoforms of CXCL12 required CXCR7 scav ...[more]
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