Ontology highlight
ABSTRACT:
SUBMITTER: Javaid S
PROVIDER: S-EPMC4034764 | biostudies-literature | 2013 Dec
REPOSITORIES: biostudies-literature
Javaid Sarah S Zhang Jianmin J Anderssen Endre E Black Josh C JC Wittner Ben S BS Tajima Ken K Ting David T DT Smolen Gromoslaw A GA Zubrowski Matthew M Desai Rushil R Maheswaran Shyamala S Ramaswamy Sridhar S Whetstine Johnathan R JR Haber Daniel A DA
Cell reports 20131219 6
Epithelial-mesenchymal transition (EMT) is thought to contribute to cancer metastasis, but its underlying mechanisms are not well understood. To define early steps in this cellular transformation, we analyzed human mammary epithelial cells with tightly regulated expression of Snail-1, a master regulator of EMT. After Snail-1 induction, epithelial markers were repressed within 6 hr, and mesenchymal genes were induced at 24 hr. Snail-1 binding to its target promoters was transient (6-48 hr) despit ...[more]