CBX7 modulates the expression of genes critical for cancer progression.

ABSTRACT:

Background

We have previously shown that the expression of CBX7 is drastically decreased in several human carcinomas and that its expression progressively decreases with the appearance of a highly malignant phenotype. The aim of our study has been to investigate the mechanism by which the loss of CBX7 expression may contribute to the emergence of a more malignant phenotype.

Methods

We analyzed the gene expression profile of a thyroid carcinoma cell line after the restoration of CBX7 and, then, analyzed the transcriptional regulation of identified genes. Finally, we evaluated the expression of CBX7 and regulated genes in a panel of thyroid and lung carcinomas.

Results

We found that CBX7 negatively or positively regulates the expression of several genes (such as SPP1, S

SUBMITTER: Pallante P 

PROVIDER: S-EPMC4035280 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature