Ontology highlight
ABSTRACT:
SUBMITTER: Yan K
PROVIDER: S-EPMC4035537 | biostudies-literature | 2014 May
REPOSITORIES: biostudies-literature
Yan Kenneth K Wu Qiulian Q Yan Diana H DH Lee Christine H CH Rahim Nasiha N Tritschler Isabel I DeVecchio Jennifer J Kalady Matthew F MF Hjelmeland Anita B AB Rich Jeremy N JN
Genes & development 20140501 10
Glioblastomas are the most prevalent and lethal primary brain tumor and are comprised of hierarchies with self-renewing cancer stem cells (CSCs) at the apex. Like neural stem cells (NSCs), CSCs reside in functional niches that provide essential cues to maintain the cellular hierarchy. Bone morphogenetic proteins (BMPs) instruct NSCs to adopt an astrocyte fate and are proposed as anti-CSC therapies to induce differentiation, but, paradoxically, tumors express high levels of BMPs. Here we demonstr ...[more]