Dataset Information

Effects of established BMI-associated loci on obesity-related traits in a French representative population sample.

ABSTRACT:

Background

Genome-wide association studies have identified variants associated with obesity-related traits, such as the body mass index (BMI). We sought to determine how the combination of 31 validated, BMI-associated loci contributes to obesity- and diabetes-related traits in a French population sample. The MONA LISA Lille study (1578 participants, aged 35-74) constitutes a representative sample of the population living in Lille (northern France). Genetic variants were considered both individually and combined into a genetic predisposition score (GPS).

Results

Individually, 25 of 31 SNPs showed directionally consistent effects on BMI. Four loci (FTO, FANCL, MTIF3 and NUDT3) reached nominal significance (p???0.05) for their association with anthropometric traits. When considering the combined effect of the 31 SNPs, each additional risk allele of the GPS was significantly associated with an increment in the mean [95% CI] BMI of 0.13 [0.07-0.20] kg/m2 (p?=?6.3x10-5) and a 3% increase in the risk of obesity (p?=?0.047). The GPS explained 1% of the variance in the BMI. Furthermore, the GPS was associated with higher fasting glycaemia (p?=?0.04), insulinaemia (p?=?0.008), HbA1c levels (p?=?0.01) and HOMA-IR scores (p?=?0.0003) and a greater risk of type 2 diabetes (OR [95% CI]?=?1.06 [1.00-1.11], p?=?0.03). However, these associations were no longer statistically significant after adjustment for BMI.

Conclusion

Our results show that the GPS was associated with a higher BMI and an insulin-resistant state (mediated by BMI) in a population in northern France.

SUBMITTER: Goumidi L

PROVIDER: S-EPMC4035696 | biostudies-literature | 2014 May

REPOSITORIES: biostudies-literature

ACCESS DATA

Publications

Effects of established BMI-associated loci on obesity-related traits in a French representative population sample.

Goumidi Louisa L Cottel Dominique D Dallongeville Jean J Amouyel Philippe P Meirhaeghe Aline A

BMC genetics 20140523

<h4>Background</h4>Genome-wide association studies have identified variants associated with obesity-related traits, such as the body mass index (BMI). We sought to determine how the combination of 31 validated, BMI-associated loci contributes to obesity- and diabetes-related traits in a French population sample. The MONA LISA Lille study (1578 participants, aged 35-74) constitutes a representative sample of the population living in Lille (northern France). Genetic variants were considered both i ...[more]

PMID: 24885863

Similar Datasets

Project description:Background and aimsObesity is a growing public health concern in Bangladesh, which is influenced by a complex interplay of genetic and environmental factors. The genetic variant rs9939609 of the FTO (fat mass and obesity-associated) gene has been found to be associated with an increased risk for obesity, depending on the population studied. The purpose of this cross-sectional study is to examine the relationship between the FTO gene polymorphism (rs9939609) and lifestyle-related risk factors, and their impact on obesity-related traits and biochemical parameters in the Bangladeshi population.MethodsA total of 280 participants were enrolled in this study, comprising of 140 individuals with overweight and obesity (body mass index [BMI] ≥ 23.0) and 140 non-overweight healthy individuals (18.5 ≤ BMI ≥ 22.9). Demographic information, dietary behaviors, and physical activity-related data were collected using a structured questionnaire. Additionally, anthropometric assessments and measurements of biochemical parameters such as lipid profile and C-reactive protein were performed. The amplification refractory mutation system-polymerase chain reaction technique was used to identify single-nucleotide polymorphism in the FTO gene. Descriptive statistics, χ,2 and one-way ANOVA were performed to evaluate the relationships between independent and dependent variables.ResultsThe presence of rs9939609 was strongly associated with the obesity risk factors of increased BMI, cholesterol, triglycerides, and low-density lipoprotein. We also found a significant association (p < 0.05) of rs9939609 with overweight and obesity in codominant AA versus TT (odds ratio [OR] = 0.299, 95% CI: 0.129-0.695) and AA versus AT (OR = 2.273, 95% CI: 1.023-5.053), recessive TT versus AA+AT (OR = 5.154, 95% CI: 2.463-10.782), and overdominant AT versus AA+TT (OR = 0.244, 95% CI: 0.122-0.488) models.ConclusionFTO variant rs9939609 is significantly linked to obesity and an increased risk of hyperlipidemia in the Bangladeshi population. However, this association is intertwined with environmental factors such as diet and physical activity.

Dataset Information

Effects of established BMI-associated loci on obesity-related traits in a French representative population sample.

Background

Results

Conclusion

Publications

Effects of established BMI-associated loci on obesity-related traits in a French representative population sample.

Similar Datasets

OmicsDI is part of the ELIXIR infrastructure

Tweets