Ontology highlight
ABSTRACT:
SUBMITTER: Briseno-Roa L
PROVIDER: S-EPMC4036237 | biostudies-literature | 2014 Apr
REPOSITORIES: biostudies-literature
Briseño-Roa Luis L Bessereau Jean-Louis JL
The Journal of biological chemistry 20140311 16
Correct positioning of neurotransmitter-gated receptors at postsynapses is essential for synaptic transmission. At Caenorhabditis elegans neuromuscular junctions, clustering of levamisole-sensitive acetylcholine receptors (L-AChRs) requires the muscle-secreted scaffolding protein LEV-9, a multidomain factor containing complement control protein (CCP) modules. Here we show that LEV-9 needs to be cleaved at its C terminus to exert its function. LEV-9 cleavage is not required for trafficking nor se ...[more]