Ontology highlight
ABSTRACT:
SUBMITTER: Salinas M
PROVIDER: S-EPMC4036345 | biostudies-literature | 2014 May
REPOSITORIES: biostudies-literature
Salinas Miguel M Besson Thomas T Delettre Quentin Q Diochot Sylvie S Boulakirba Sonia S Douguet Dominique D Lingueglia Eric E
The Journal of biological chemistry 20140402 19
Acid-sensing ion channels (ASICs) are neuronal proton-gated cation channels associated with nociception, fear, depression, seizure, and neuronal degeneration, suggesting roles in pain and neurological and psychiatric disorders. We have recently discovered black mamba venom peptides called mambalgin-1 and mambalgin-2, which are new three-finger toxins that specifically inhibit with the same pharmacological profile ASIC channels to exert strong analgesic effects in vivo. We now combined bioinforma ...[more]