Iron and cancer: more ore to be mined.
Ontology highlight
ABSTRACT:
SUBMITTER: Torti SV
PROVIDER: S-EPMC4036554 | biostudies-literature | 2013 May
REPOSITORIES: biostudies-literature
Publications
Iron and cancer: more ore to be mined.
Torti Suzy V SV Torti Frank M FM
Nature reviews. Cancer 20130418 5
Iron is an essential nutrient that facilitates cell proliferation and growth. However, iron also has the capacity to engage in redox cycling and free radical formation. Therefore, iron can contribute to both tumour initiation and tumour growth; recent work has also shown that iron has a role in the tumour microenvironment and in metastasis. Pathways of iron acquisition, efflux, storage and regulation are all perturbed in cancer, suggesting that reprogramming of iron metabolism is a central aspec ...[more]
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