β1-adrenergic receptor activation enhances memory in Alzheimer's disease model.

ABSTRACT:

Objective

Deficits in social recognition and learning of social cues are major symptoms of neurodegenerative disorders such as Alzheimer's disease (AD). Here we studied the role of β₁-noradrenergic signaling in cognitive function to determine whether it could be used as a potential therapeutic target for AD.

Methods

Using pharmacological, biochemical and behavioral tools, we assessed social recognition and the β₁-adrenergic receptor (ADR) and its downstream PKA/phospho-CREB (pCREB) signaling cascade in the medial amygdala (MeA) in Thy1-hAPP^Lond/Swe+(APP) mouse model of AD.

Results

Our results demonstrated that APP mice display a significant social recognition deficit which is dependent on the β₁-adrenergic system. Moreover,

SUBMITTER: Coutellier L 

PROVIDER: S-EPMC4036739 | biostudies-literature | 2014 May

REPOSITORIES: biostudies-literature