Ontology highlight
ABSTRACT:
SUBMITTER: Arts GJ
PROVIDER: S-EPMC403715 | biostudies-literature | 2003 Oct
REPOSITORIES: biostudies-literature
Arts Gert-Jan GJ Langemeijer Ellen E Tissingh Rudi R Ma Libin L Pavliska Heidi H Dokic Kristina K Dooijes Richele R Mesić Emir E Clasen Remko R Michiels Frits F van der Schueren Jan J Lambrecht Mark M Herman Sofie S Brys Reginald R Thys Kim K Hoffmann Marcel M Tomme Peter P van Es Helmuth H
Genome research 20030915 10
RNA interference is a powerful tool for studying gene function and for drug target discovery in diverse organisms and cell types. In mammalian systems, small interfering RNAs (siRNAs), or DNA plasmids expressing these siRNAs, have been used to down-modulate gene expression. However, inefficient transfection protocols, in particular, for primary cell types, have hampered the use of these tools in disease-relevant cellular assays. To be able to use this technology for genome-wide function screenin ...[more]