Ontology highlight
ABSTRACT:
SUBMITTER: Park JH
PROVIDER: S-EPMC4037565 | biostudies-literature | 2013 Jan
REPOSITORIES: biostudies-literature
Organic & biomolecular chemistry 20130101 1
The use of the copper(I)-assisted azide-alkyne cycloaddition (CuAAC, or "click" reaction) as a method of β-hairpin stabilization was investigated at several different positions to determine the impact on hairpin structure and function, including hydrogen bonded sites, non-hydrogen bonded sites, and at the peptide termini. The role of the turn sequence in the peptide and the chain length of the azide were also investigated. It was determined that the CuAAC reaction was a suitable method for locki ...[more]