Ontology highlight
ABSTRACT:
SUBMITTER: Ritson DJ
PROVIDER: S-EPMC4037592 | biostudies-literature | 2014 May
REPOSITORIES: biostudies-literature
Journal of molecular evolution 20140416 5
Soon after the origin of RNA-based life, depletion of prebiotically synthesised ribonucleotides would have driven the evolution of a biosynthetic pathway to these key building blocks. Ribozyme-catalysed nucleosidation-the key biosynthetic step-requires that ribose and the nucleobases are produced by abiotic chemistry and are relatively stable to the conditions of their synthesis. The most plausible prebiotic synthesis of sugars involves photoreduction of cyanohydrins by hydrogen sulphide in the ...[more]