Ontology highlight
ABSTRACT:
SUBMITTER: Mazzone M
PROVIDER: S-EPMC4037868 | biostudies-literature | 2009 Mar
REPOSITORIES: biostudies-literature
Mazzone Massimiliano M Dettori Daniela D de Oliveira Rodrigo Leite RL Loges Sonja S Schmidt Thomas T Jonckx Bart B Tian Ya-Min YM Lanahan Anthony A AA Pollard Patrick P de Almodovar Carmen Ruiz CR De Smet Frederik F Vinckier Stefan S Aragonés Julián J Debackere Koen K Luttun Aernout A Wyns Sabine S Jordan Benedicte B Pisacane Alberto A Gallez Bernard B Lampugnani Maria Grazia MG Dejana Elisabetta E Simons Michael M Ratcliffe Peter P Maxwell Patrick P Carmeliet Peter P
Cell 20090212 5
A key function of blood vessels, to supply oxygen, is impaired in tumors because of abnormalities in their endothelial lining. PHD proteins serve as oxygen sensors and may regulate oxygen delivery. We therefore studied the role of endothelial PHD2 in vessel shaping by implanting tumors in PHD2(+/-) mice. Haplodeficiency of PHD2 did not affect tumor vessel density or lumen size, but normalized the endothelial lining and vessel maturation. This resulted in improved tumor perfusion and oxygenation ...[more]