Ontology highlight
ABSTRACT:
SUBMITTER: Bhattacharya C
PROVIDER: S-EPMC4038340 | biostudies-literature | 2014 May
REPOSITORIES: biostudies-literature
Bhattacharya Chandrabali C Yu Zhiqiang Z Rishel Michael J MJ Hecht Sidney M SM
Biochemistry 20140513 20
Recently, we reported that both bleomycin (BLM) and its disaccharide, conjugated to the cyanine dye Cy5**, bound selectively to cancer cells. Thus, the disaccharide moiety alone recapitulates the tumor cell targeting properties of BLM. Here, we demonstrate that the conjugate of the BLM carbamoylmannose moiety with Cy5** showed tumor cell selective binding and also enhanced cellular uptake in most cancer cell lines. The carbamoyl functionality was required for tumor cell targeting. A dye conjugat ...[more]