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Content-specific fronto-parietal synchronization during visual working memory.

ABSTRACT: Lateral prefrontal and posterior parietal cortical areas exhibit task-dependent activation during working memory tasks in humans and monkeys. Neurons in these regions become synchronized during attention-demanding tasks, but the contribution of these interactions to working memory is largely unknown. Using simultaneous recordings of neural activity from multiple areas in both regions, we find widespread, task-dependent, and content-specific synchronization of activity across the fronto-parietal network during visual working memory. The patterns of synchronization are prevalent among stimulus-selective neurons and are governed by influences arising in parietal cortex. These results indicate that short-term memories are represented by large-scale patterns of synchronized activity across the fronto-parietal network.

SUBMITTER: Salazar RF

PROVIDER: S-EPMC4038369 | biostudies-literature | 2012 Nov

REPOSITORIES: biostudies-literature

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Content-specific fronto-parietal synchronization during visual working memory.

Salazar R F RF Dotson N M NM Bressler S L SL Gray C M CM

Science (New York, N.Y.) 20121101 6110

Lateral prefrontal and posterior parietal cortical areas exhibit task-dependent activation during working memory tasks in humans and monkeys. Neurons in these regions become synchronized during attention-demanding tasks, but the contribution of these interactions to working memory is largely unknown. Using simultaneous recordings of neural activity from multiple areas in both regions, we find widespread, task-dependent, and content-specific synchronization of activity across the fronto-parietal ...[more]

PMID: 23118014

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