Alzheimer's disease risk genes and the age-at-onset phenotype.
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ABSTRACT:
SUBMITTER: Thambisetty M
PROVIDER: S-EPMC4038407 | biostudies-literature | 2013 Nov
REPOSITORIES: biostudies-literature
Publications
Alzheimer's disease risk genes and the age-at-onset phenotype.
Thambisetty Madhav M An Yang Y Tanaka Toshiko T
Neurobiology of aging 20130717 11
Despite the recent identification of several novel risk genes for Alzheimer's disease (AD), little is known about their influence on the age at onset (AAO) of AD. The AAO is a phenotype with a heritable component distinct from disease risk and may be a useful trait to study in the context of developing interventions for delaying the onset of AD. We studied the influence of 10 recently identified AD risk genes and APOE in relation to AAO in a large cohort of AD patients (N = 2569). We find that t ...[more]
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