Ontology highlight
ABSTRACT:
SUBMITTER: Kallgren SP
PROVIDER: S-EPMC4038458 | biostudies-literature | 2014
REPOSITORIES: biostudies-literature
Kallgren Scott P SP Andrews Stuart S Tadeo Xavier X Hou Haitong H Moresco James J JJ Tu Patricia G PG Yates John R JR Nagy Peter L PL Jia Songtao S
PLoS genetics 20140529 5
Heterochromatin preferentially assembles at repetitive DNA elements, playing roles in transcriptional silencing, recombination suppression, and chromosome segregation. The RNAi machinery is required for heterochromatin assembly in a diverse range of organisms. In fission yeast, RNA splicing factors are also required for pericentric heterochromatin assembly, and a prevailing model is that splicing factors provide a platform for siRNA generation independently of their splicing activity. Here, by s ...[more]