Ontology highlight
ABSTRACT:
SUBMITTER: Raviv S
PROVIDER: S-EPMC4038462 | biostudies-literature | 2014
REPOSITORIES: biostudies-literature
PLoS genetics 20140529 5
During organogenesis, PAX6 is required for establishment of various progenitor subtypes within the central nervous system, eye and pancreas. PAX6 expression is maintained in a variety of cell types within each organ, although its role in each lineage and how it acquires cell-specific activity remain elusive. Herein, we aimed to determine the roles and the hierarchical organization of the PAX6-dependent gene regulatory network during the differentiation of the retinal pigmented epithelium (RPE). ...[more]