Ontology highlight
ABSTRACT:
SUBMITTER: Condamine T
PROVIDER: S-EPMC4038578 | biostudies-literature | 2014 Jun
REPOSITORIES: biostudies-literature
Condamine Thomas T Kumar Vinit V Ramachandran Indu R IR Youn Je-In JI Celis Esteban E Finnberg Niklas N El-Deiry Wafik S WS Winograd Rafael R Vonderheide Robert H RH English Nickolas R NR Knight Stella C SC Yagita Hideo H McCaffrey Judith C JC Antonia Scott S Hockstein Neil N Witt Robert R Masters Gregory G Bauer Thomas T Gabrilovich Dmitry I DI
The Journal of clinical investigation 20140501 6
Myeloid-derived suppressor cells (MDSCs) dampen the immune response thorough inhibition of T cell activation and proliferation and often are expanded in pathological conditions. Here, we studied the fate of MDSCs in cancer. Unexpectedly, MDSCs had lower viability and a shorter half-life in tumor-bearing mice compared with neutrophils and monocytes. The reduction of MDSC viability was due to increased apoptosis, which was mediated by increased expression of TNF-related apoptosis-induced ligand re ...[more]