Ontology highlight
ABSTRACT:
SUBMITTER: Kong G
PROVIDER: S-EPMC4038579 | biostudies-literature | 2014 Jun
REPOSITORIES: biostudies-literature
Kong Guangyao G Wunderlich Mark M Yang David D Ranheim Erik A EA Young Ken H KH Wang Jinyong J Chang Yuan-I YI Du Juan J Liu Yangang Y Tey Sin Ruow SR Zhang Xinmin X Juckett Mark M Mattison Ryan R Damnernsawad Alisa A Zhang Jingfang J Mulloy James C JC Zhang Jing J
The Journal of clinical investigation 20140508 6
Overactive RAS signaling is prevalent in juvenile myelomonocytic leukemia (JMML) and the myeloproliferative variant of chronic myelomonocytic leukemia (MP-CMML) in humans, and both are refractory to conventional chemotherapy. Conditional activation of a constitutively active oncogenic Nras (NrasG12D/G12D) in murine hematopoietic cells promotes an acute myeloproliferative neoplasm (MPN) that recapitulates many features of JMML and MP-CMML. We found that NrasG12D/G12D-expressing HSCs, which serve ...[more]