Unknown

Dataset Information

0

Sox4 is a key oncogenic target in C/EBP? mutant acute myeloid leukemia.

ABSTRACT: Mutation or epigenetic silencing of the transcription factor C/EBP? is observed in ?10% of patients with acute myeloid leukemia (AML). In both cases, a common global gene expression profile is observed, but downstream targets relevant for leukemogenesis are not known. Here, we identify Sox4 as a direct target of C/EBP? whereby its expression is inversely correlated with C/EBP? activity. Downregulation of Sox4 abrogated increased self-renewal of leukemic cells and restored their differentiation. Gene expression profiles of leukemia-initiating cells (LICs) from both Sox4 overexpression and murine C/EBP? mutant AML models clustered together but differed from other types of AML. Our data demonstrate that Sox4 overexpression resulting from C/EBP? inactivation contributes to the development of leukemia with a distinct LIC phenotype.

SUBMITTER: Zhang H 

PROVIDER: S-EPMC4038627 | biostudies-literature | 2013 Nov

REPOSITORIES: biostudies-literature

Json Xml
altmetric image

Publications

Mutation or epigenetic silencing of the transcription factor C/EBPα is observed in ∼10% of patients with acute myeloid leukemia (AML). In both cases, a common global gene expression profile is observed, but downstream targets relevant for leukemogenesis are not known. Here, we identify Sox4 as a direct target of C/EBPα whereby its expression is inversely correlated with C/EBPα activity. Downregulation of Sox4 abrogated increased self-renewal of leukemic cells and restored their differentiation.  ...[more]

Similar Datasets

Transcriptomics Sox4 is a key oncogenic target in C/EBP? mutant Acute Myeloid Leukemia
2013-03-23 | E-GEOD-45430 | biostudies-arrayexpress
Genomics Sox4 is a key oncogenic target in C/EBPa mutant Acute Myeloid Leukemia
2014-01-08 | E-GEOD-50565 | biostudies-arrayexpress
Transcriptomics Sox4 is a key oncogenic target in C/EBPα mutant Acute Myeloid Leukemia
2013-03-23 | GSE45430 | GEO
Genomics Sox4 is a key oncogenic target in C/EBPa mutant Acute Myeloid Leukemia
2014-01-08 | GSE50565 | GEO
Unknown C/EBP? overrides epigenetic reprogramming by oncogenic transcription factors in acute myeloid leukemia.
| S-EPMC5812331 | biostudies-literature
Unknown Mutant NPM1 Directly Regulates Oncogenic Transcription in Acute Myeloid Leukemia.
| S-EPMC10084473 | biostudies-literature
Unknown Oncogenic role of lncRNA CRNDE in acute promyelocytic leukemia and NPM1-mutant acute myeloid leukemia.
| S-EPMC7658230 | biostudies-literature
Unknown SOX4 enables oncogenic survival signals in acute lymphoblastic leukemia.
| S-EPMC3538327 | biostudies-literature
Unknown Targeting Oncogenic Signaling in Mutant FLT3 Acute Myeloid Leukemia: The Path to Least Resistance.
| S-EPMC6214138 | biostudies-literature
Unknown Targeting CDK1 promotes FLT3-activated acute myeloid leukemia differentiation through C/EBP?.
| S-EPMC3408728 | biostudies-literature